Weiss joined the staff of the Holocaust & Humanity Center in 2004. She was appointed executive director in 2007 – working to formulate lasting partnerships with organizations and educational institutions locally, nationally, and internationally. As the granddaughter of Holocaust survivors, Weiss brings a personal connection and passion to her work. She is a graduate of a competitive course at the esteemed Yad Vashem International School for Holocaust Studies, in addition to completing the Lerner Fellowship through the Jewish Foundation for the Righteous at Columbia University. Weiss has impacted the community in several roles outside of her work at the Holocaust & Humanity Center. She served as director of the Jewish Community Relations Council at the Jewish Federation of Cincinnati from 2011 to 2017. Building bridges between Jewish and non-Jewish communities, Weiss advocated on behalf of the Jewish community, and Israel, during a time when antisemitism and hate-related crimes increased locally and nationwide.